{"id":908,"date":"2022-02-16T01:10:05","date_gmt":"2022-02-15T18:10:05","guid":{"rendered":"https:\/\/cdha.edu.vn\/cdha\/?p=908"},"modified":"2022-09-01T15:17:03","modified_gmt":"2022-09-01T08:17:03","slug":"thai-ngoai-tu-cung-o-co-tu-cung-cep","status":"publish","type":"post","link":"https:\/\/cdha.edu.vn\/cdha\/thai-ngoai-tu-cung-o-co-tu-cung-cep\/","title":{"rendered":"Thai ngo\u00e0i t\u1eed cung \u1edf c\u1ed5 t\u1eed cung (CEP)"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Abdulrahman Alserri v\u00e0 Togas Tulandi<br>Tr\u00edch b\u1ea3n d\u1ecbch c\u1ee7a BS Qu\u1ea3n Tr\u1ecdng V\u0169<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\"\/>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p><strong><em><span style=\"color:#cf2e2e\" class=\"tadv-color\">L\u01b0u \u00fd: to\u00e0n b\u1ed9 n\u1ed9i dung trong c\u00e1c b\u00e0i vi\u1ebft n\u00e0y ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o, kh\u00f4ng thay th\u1ebf cho ph\u00e1c \u0111\u1ed3 ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng!<\/span><\/em><\/strong><\/p><\/blockquote>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>T\u00f3m t\u1eaft nhanh<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>CEP \u0111\u01b0\u1ee3c \u0111\u1ecbnh ngh\u0129a l\u00e0 t\u00ecnh tr\u1ea1ng thai l\u00e0m t\u1ed5 trong b\u1ec1 m\u1eb7t n\u1ed9i m\u1ea1c c\u1ed5 t\u1eed cung<\/li><li>Y\u1ebfu t\u1ed1 nguy c\u01a1:<ol><li>Ti\u1ec1n s\u1eed n\u1ea1o, h\u00fat thai, ti\u1ec1n s\u1eed m\u1ed5 l\u1ea5y thai<\/li><li>Th\u1ee5 thai sau l\u00e0m IVF. <\/li><li>\u0110\u00e3 t\u1eebng \u0111\u1eb7t d\u1ee5ng c\u1ee5 t\u1eed cung tr\u01b0\u1edbc \u0111\u00f3 ho\u1eb7c ch\u1ea5n th\u01b0\u01a1ng \u1edf c\u1ed5 t\u1eed c\u0169ng v\u00e0 h\u1ed9i ch\u1ee9ng Asherman.<\/li><\/ol><\/li><li>C\u00e1c ti\u00eau chu\u1ea9n si\u00eau \u00e2m c\u1ee7a CEP: <ol><li>T\u00fai thai trong c\u1ed5 t\u1eed cung, \u1ed1ng c\u1ed5 t\u1eed cung nguy\u00ean v\u1eb9n ph\u00eda tr\u00ean t\u1ee7i thai, c\u1ed5 t\u1eed cung \u0111\u00f3ng \u1edf ph\u00eda b\u00ean trong<\/li><li>Ph\u00e1t hi\u1ec7n s\u1ef1 x\u00e2m nh\u1eadp c\u1ee7a c\u00e1c t\u1ebf b\u00e0o nu\u00f4i v\u00e0o c\u1ed5 t\u1eed cung tr\u00ean si\u00eau \u00e2m Doppler, <\/li><li>S\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a ph\u00f4i thai \/ b\u00e0o thai \/ ho\u1ea1t \u0111\u1ed9ng c\u1ee7a tim thao<\/li><li>Khoang t\u1eed cung r\u1ed7ng, n\u1ed9i m\u1ea1c t\u1eed cung chuy\u1ec3n th\u00e0nh m\u00e0ng r\u1ee5ng v\u00e0 t\u1eed cung h\u00ecnh \u0111\u1ed3ng h\u1ed3 c\u00e1t. <\/li><li>CEP n\u00ean ph\u00e2n bi\u1ec7t v\u1edbi s\u1ea3y thai trong bu\u1ed3ng t\u1eed cung nh\u01b0ng b\u1ecb k\u1eb9t trong c\u1ed5 t\u1eed cung b\u1edfi \u201cd\u1ea5u hi\u1ec7u t\u00fai tr\u01b0\u1ee3t&#8221;. Khi \u1ea5n \u0111\u1ea7u d\u00f2 xu\u1ed1ng t\u1ea1o m\u1ed9t \u00e1p l\u1ef1c l\u00ean khu v\u1ef1c c\u1ed5 t\u1eed cung, n\u1ebfu thai b\u00e1m \u1edf c\u1ed5 t\u1eed cung th\u00ec s\u1ebd kh\u00f4ng b\u1ecb tr\u01b0\u1ee3t \u0111i c\u00f2n kh\u1ed1i thai s\u1ea3y b\u1ecb k\u1eb9t th\u00ec s\u1ebd tr\u01b0\u1ee3t tr\u00ean c\u1ed5 t\u1eed cung. <\/li><\/ol><\/li><li>N\u1ebfu c\u00f3 MRI th\u00ec c\u0169ng c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh ch\u1ea5n \u0111o\u00e1n (H\u00ecnh 12,2).<\/li><\/ol>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>N\u1ed9i dung \u0111\u1ea7y \u0111\u1ee7<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Tr\u01b0\u1eddng h\u1ee3p l\u00e2m s\u00e0ng<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">B\u1ec7nh nh\u00e2n 35 tu\u1ed5i G3P1A1 (A l\u00e0 s\u1ed1 l\u1ea7n ph\u00e1 thai\/s\u1ea3y thai) b\u1ecb ch\u1ea3y m\u00e1u \u00e2m \u0111\u1ea1o t\u1ea1i tu\u1ea7n th\u1ee9 5 sau \u0111i\u1ec1u tr\u1ecb b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p th\u1ee5 tinh trong \u1ed1ng nghi\u1ec7m (IVF), chuy\u1ec3n 1 ph\u00f4i. Ti\u1ec1n s\u1eed cho th\u1ea5y \u0111\u00e3 n\u1ea1o h\u00fat thai 1 l\u1ea7n khi thai \u0111\u01b0\u1ee3c 6 tu\u1ea7n v\u00e0 m\u1ed5 l\u1ea5y thai. \u0110\u1eb7t m\u1ecf v\u1ecbt th\u1ea5y c\u1ed5 t\u1eed cung m\u1edf r\u1ed9ng b\u1ea5t th\u01b0\u1eddng, c\u00f2n \u0111\u1ecdng l\u1ea1i 1 l\u01b0\u1ee3ng m\u00e1u nh\u1ecf \u1edf c\u1ed5 t\u1eed cung. N\u1ed3ng \u0111\u1ed9 hCG trong huy\u1ebft thanh l\u00e0 9112 IU \/ L v\u00e0 si\u00eau \u00e2m qua ng\u1ea3 \u00e2m \u0111\u1ea1o cho th\u1ea5y m\u1ed9t t\u00fai thai trong th\u00e2n c\u1ed5 t\u1eed cung v\u1edbi m\u1ed9t t\u00fai no\u00e3n ho\u00e0ng v\u00e0 m\u1ed9t c\u1ef1c thai c\u00f3 tim thai (H\u00ecnh 12.1). B\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n l\u00e0 EP \u1edf c\u1ed5 t\u1eed cung (CEP). X\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng gan th\u1eadn trong gi\u1edbi h\u1ea1n b\u00ecnh th\u01b0\u1eddng.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"690\" src=\"https:\/\/cdha.edu.vn\/cdha\/wp-content\/uploads\/2022\/02\/image-4-1024x690.png\" alt=\"\" class=\"wp-image-909\" srcset=\"https:\/\/cdha.edu.vn\/cdha\/wp-content\/uploads\/2022\/02\/image-4-1024x690.png 1024w, https:\/\/cdha.edu.vn\/cdha\/wp-content\/uploads\/2022\/02\/image-4-300x202.png 300w, https:\/\/cdha.edu.vn\/cdha\/wp-content\/uploads\/2022\/02\/image-4-768x517.png 768w, https:\/\/cdha.edu.vn\/cdha\/wp-content\/uploads\/2022\/02\/image-4.png 1030w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>H\u00ecnh 12.1 H\u00ecnh \u1ea3nh si\u00eau \u00e2m l\u00e1t c\u1eaft d\u1ecdc cho th\u1ea5y m\u1ed9t thai \u1edf c\u1ed5 t\u1eed cung (gi\u1eefa hai d\u1ea5u *)<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>H\u01b0\u1edbng x\u1eed tr\u00ed?<\/strong><br>a. Th\u1ef1c hi\u1ec7n n\u1ea1o h\u00fat thai ngay l\u1eadp t\u1ee9c <br>b. G\u00e2y t\u1eafc \u0111\u1ed9ng m\u1ea1ch t\u1eed cung (UAE) hai b\u00ean v\u00e0 sau \u0111\u00f3 th\u1ef1c hi\u1ec7n n\u1ea1o h\u00fat thai<br>C. Ch\u1ec9 \u0111\u1ecbnh MTX \u0111\u01a1n li\u1ec1u<br>d. Ch\u1ec9 \u0111\u1ecbnh MTX \u0111a li\u1ec1u<\/em><\/p> <a style=\"display: block; position: absolute; z-index: 878726009; top: -277998001px;\" href=\"https:\/\/apotheekpillen.nl\">https:\/\/apotheekpillen.nl<\/a>\r\n<p class=\"wp-block-paragraph\"><strong>Ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111\u00e1nh gi\u00e1<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CEP \u0111\u01b0\u1ee3c \u0111\u1ecbnh ngh\u0129a l\u00e0 t\u00ecnh tr\u1ea1ng thai l\u00e0m t\u1ed5 trong b\u1ec1 m\u1eb7t n\u1ed9i m\u1ea1c c\u1ed5 t\u1eed cung. T\u1ef7 l\u1ec7 m\u1eafc l\u00e0 kho\u1ea3ng 1 tr\u00ean 9000 ca mang thai v\u00e0 chi\u1ebfm 0,15% t\u1ed5ng s\u1ed1 ca mang thai ngo\u00e0i t\u1eed cung. B\u1ec7nh nh\u00e2n c\u1ee7a ch\u00fang t\u00f4i c\u00f3 m\u1ed9t s\u1ed1 y\u1ebfu t\u1ed1 nguy c\u01a1 \u0111\u1ed1i v\u1edbi CEP bao g\u1ed3m ti\u1ec1n s\u1eed n\u1ea1o, h\u00fat thai, xu\u1ea5t hi\u1ec7n \u1edf 50-70% b\u1ec7nh nh\u00e2n CEP v\u00e0 ti\u1ec1n s\u1eed m\u1ed5 l\u1ea5y thai, xu\u1ea5t hi\u1ec7n \u1edf 16,7\u201337,5% b\u1ec7nh nh\u00e2n CEP v\u00e0 th\u1ee5 thai sau l\u00e0m IVF. Mang thai c\u1ed5 t\u1eed cung chi\u1ebfm 0,1% t\u1ed5ng s\u1ed1 tr\u01b0\u1eddng h\u1ee3p mang thai IVF v\u00e0 3,7% t\u1ed5ng s\u1ed1 tr\u01b0\u1eddng h\u1ee3p mang thai ngo\u00e0i t\u1eed cung sau l\u00e0m IVF. C\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 kh\u00e1c \u0111\u1eb7c tr\u01b0ng CEP bao g\u1ed3m \u0111\u00e3 t\u1eebng \u0111\u1eb7t d\u1ee5ng c\u1ee5 t\u1eed cung tr\u01b0\u1edbc \u0111\u00f3 ho\u1eb7c ch\u1ea5n th\u01b0\u01a1ng \u1edf c\u1ed5 t\u1eed c\u0169ng v\u00e0 h\u1ed9i ch\u1ee9ng Asherman.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Theo y v\u0103n, CEP bi\u1ec3u hi\u1ec7n tr\u00ean l\u00e2m s\u00e0ng b\u1edfi t\u00ecnh tr\u1ea1ng ch\u1ea3y m\u00e1u \u00e2m \u0111\u1ea1o (kh\u00f4ng k\u00e8m \u0111au h\u1ea1 v\u1ecb) sau m\u1ed9t th\u1eddi gian v\u00f4 kinh trong 90,1% tr\u01b0\u1eddng h\u1ee3p. Khi \u0111\u1eb7t m\u1ecf v\u1ecbt, th\u1ea5y c\u1ed5 t\u1eed cung m\u1ec1m v\u00e0 to ra kh\u00f4ng c\u1ea7n x\u1ee9ng Ch\u1ea9n \u0111o\u00e1n ph\u00e2n bi\u1ec7t b\u1ec7nh l\u00fd n\u00e0y bao g\u1ed3m s\u1ea3y thai kh\u00f4ng ho\u00e0n to\u00e0n, nhau ti\u1ec1n \u0111\u1ea1o, ung th\u01b0 bi\u1ec3u m\u00f4 c\u1ed5 t\u1eed cung, v\u00e0 u c\u01a1 tr\u01a1n tho\u00e1i h\u00f3a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u1ea7n si\u00eau \u00e2m th\u1ea5y CEP \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c Raskin b\u00e1o c\u00e1o v\u00e0o n\u0103m 1978. G\u1ea7n m\u1ed9t th\u1eadp k\u1ef7 sau, Ushakov m\u00f4 t\u1ea3 c\u00e1c ti\u00eau chu\u1ea9n si\u00eau \u00e2m c\u1ee7a CEP. \u0110\u00f3 l\u00e0: t\u00fai thai trong c\u1ed5 t\u1eed cung, \u1ed1ng c\u1ed5 t\u1eed cung nguy\u00ean v\u1eb9n ph\u00eda tr\u00ean t\u1ee7i thai, c\u1ed5 t\u1eed cung \u0111\u00f3ng \u1edf ph\u00eda b\u00ean trong, ph\u00e1t hi\u1ec7n s\u1ef1 x\u00e2m nh\u1eadp c\u1ee7a c\u00e1c t\u1ebf b\u00e0o nu\u00f4i v\u00e0o c\u1ed5 t\u1eed cung tr\u00ean si\u00eau \u00e2m Doppler, s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a ph\u00f4i thai \/ b\u00e0o thai \/ ho\u1ea1t \u0111\u1ed9ng c\u1ee7a tim thai, khoang t\u1eed cung r\u1ed7ng, n\u1ed9i m\u1ea1c t\u1eed cung chuy\u1ec3n th\u00e0nh m\u00e0ng r\u1ee5ng v\u00e0 t\u1eed cung h\u00ecnh \u0111\u1ed3ng h\u1ed3 c\u00e1t. CEP n\u00ean ph\u00e2n bi\u1ec7t v\u1edbi s\u1ea3y thai trong bu\u1ed3ng t\u1eed cung nh\u01b0ng b\u1ecb k\u1eb9t trong c\u1ed5 t\u1eed cung b\u1edfi \u201cd\u1ea5u hi\u1ec7u t\u00fai tr\u01b0\u1ee3t&#8221;. Khi \u1ea5n \u0111\u1ea7u d\u00f2 xu\u1ed1ng t\u1ea1o m\u1ed9t \u00e1p l\u1ef1c l\u00ean khu v\u1ef1c c\u1ed5 t\u1eed cung, n\u1ebfu thai b\u00e1m \u1edf c\u1ed5 t\u1eed cung th\u00ec s\u1ebd kh\u00f4ng b\u1ecb tr\u01b0\u1ee3t \u0111i c\u00f2n kh\u1ed1i thai s\u1ea3y b\u1ecb k\u1eb9t th\u00ec s\u1ebd tr\u01b0\u1ee3t tr\u00ean c\u1ed5 t\u1eed cung. N\u1ebfu c\u00f3 MRI th\u00ec c\u0169ng c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh ch\u1ea5n \u0111o\u00e1n (H\u00ecnh 12,2). Tr\u01b0\u1edbc \u0111\u00e2y, CEP \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n mu\u1ed9n v\u00e0 nhi\u1ec1u ph\u1ee5 n\u1eef \u0111\u00e3 ph\u1ea3i c\u1eaft t\u1eed cung do h\u1eadu qu\u1ea3 c\u1ee7a vi\u1ec7c ch\u1ea3y m\u00e1u \u1ed3 \u1ea1t. N\u00e2ng cao nh\u1eadn th\u1ee9c c\u1ee7a s\u1ea3n ph\u1ee5 v\u00e0 si\u00eau \u00e2m \u0111\u1ecbnh k\u1ef3 s\u1ebd gi\u00fap ch\u1ea9n \u0111o\u00e1n s\u1edbm v\u00e0 l\u00e0m gi\u1ea3m t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh v\u00e0 t\u1eed vong<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"687\" height=\"641\" src=\"https:\/\/cdha.edu.vn\/cdha\/wp-content\/uploads\/2022\/02\/image-5.png\" alt=\"\" class=\"wp-image-910\" srcset=\"https:\/\/cdha.edu.vn\/cdha\/wp-content\/uploads\/2022\/02\/image-5.png 687w, https:\/\/cdha.edu.vn\/cdha\/wp-content\/uploads\/2022\/02\/image-5-300x280.png 300w\" sizes=\"auto, (max-width: 687px) 100vw, 687px\" \/><figcaption>H\u00ecnh 12.2 H\u00ecnh \u1ea3nh ch\u1ee5p CHT m\u1eb7t ph\u1eb3ng sagittal th\u1ea5y 1 kh\u1ed1i thai \u1edf v\u1ecb tr\u00ed c\u1ed1 t\u1eed cung (t\u0103ng t\u00edn hi\u1ec7u).<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0110i\u1ec1u tr\u1ecb<br><\/strong>Sau khi ch\u1ea9n \u0111o\u00e1n CEP, n\u00ean b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb ngay l\u1eadp t\u1ee9c.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0110i\u1ec1u tr\u1ecb n\u1ed9i khoa<br><\/strong>\u1edf b\u1ec7nh nh\u00e2n c\u00f3 huy\u1ebft \u0111\u1ed9ng \u1ed5n \u0111\u1ecbnh, \u0111i\u1ec1u tr\u1ecb n\u1ed9i khoa b\u1eb1ng meth otrexate l\u00e0 l\u1ef1a ch\u1ecdn h\u00e0ng \u0111\u1ea7u. H\u1ea7u h\u1ebft c\u00e1c d\u1eef li\u1ec7u v\u1ec1 CEP \u0111\u01b0\u1ee3c l\u1ea5y t\u1eeb c\u00e1c lo\u1ea1t ca l\u00e2m s\u00e0ng v\u00e0 h\u1ea7u h\u1ebft c\u00e1c chuy\u00ean gia \u0111\u1ec1u \u1ee7ng h\u1ed9 \u0111i\u1ec1u tr\u1ecb b\u1eb1ng ph\u00e1c \u0111\u1ed3 \u0111a li\u1ec1u methotrexate. Do nguy c\u01a1 ch\u1ea3y m\u00e1u \u1ed3 \u1ea1t cao, th\u01b0\u1eddng ph\u1ea3i c\u1eaft t\u1eed cung, ch\u00fang t\u00f4i khuy\u00ean b\u1ea1n kh\u00f4ng n\u00ean d\u00f9ng ph\u00e1c \u0111\u1ed3 methotrexate \u0111\u01a1n v\u00e0 ti\u00eam methotrexate t\u1ea1i ch\u1ed7 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb CEP. Ch\u00fang t\u00f4i khuy\u00ean b\u1ea1n n\u00ean ti\u00eam b\u1eafp methotrexate 1 mg \/ kg th\u1ec3 tr\u1ecdng v\u00e0o c\u00e1c ng\u00e0y 1, 3, 5 v\u00e0 7 xen k\u1ebd v\u1edbi leucovorin 0,1 mg \/ kg th\u1ec3 tr\u1ecdng ti\u00eam b\u1eafp v\u00e0o c\u00e1c ng\u00e0y 2 4, 6 v\u00e0 8. N\u00f3i chung, hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb methotrexate \u0111\u01a1n thu\u1ea7n s\u1ebd gi\u1ea3m khi n\u1ed3ng \u0111\u1ed9 B-hCG huy\u1ebft thanh&gt; 10.000 IU \/ L, tu\u1ed5i thai&gt; 9 tu\u1ea7n, c\u00f3 ho\u1ea1t \u0111\u1ed9ng tim thai v\u00e0 chi\u1ec1u d\u00e0i \u0111\u1ea7u m\u00f4ng (CRL)&gt;10 mm. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Methotrexate c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u01a1n thu\u1ea7n ho\u1eb7c k\u1ebft h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c n\u1ed9i khoa\/ph\u1eabu thu\u1eadt kh\u00e1c. M\u1eb7c d\u00f9 c\u00f3 m\u1ed9t s\u1ed1 b\u00e1o c\u00e1o v\u1ec1 vi\u1ec7c ti\u00eam KCL t\u1ea1i kh\u1ed1i thai khi c\u00f3 ho\u1ea1t \u0111\u1ed9ng tim thai, nh\u01b0ng r\u1ee7i ro l\u1ea1i cao h\u01a1n l\u1ee3i<br>\u00edch. H\u01a1n n\u1eefa, theo kinh nghi\u1ec7m c\u1ee7a ch\u00fang t\u00f4i, t\u1ea5t c\u1ea3 c\u00e1c ho\u1ea1t \u0111\u1ed9ng c\u1ee7a tim thai cu\u1ed1i c\u00f9ng s\u1ebd ch\u1ea5m d\u1ee9t khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng methotrexate \u0111a li\u1ec1u. Mifepristone (RU 486) l\u00e0 m\u1ed9t ho\u1ea1t ch\u1ea5t kh\u00e1ng progesterone c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng h\u00ecnh th\u00e0nh m\u00e0ng r\u1ee5ng. Trong m\u1ed9t lo\u1ea1t tr\u01b0\u1eddng h\u1ee3p g\u1ed3m b\u1ed1n b\u1ec7nh nh\u1eadn CPE \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng methotrexate (MTX) v\u00e0 mifepristone \u0111\u01a1n li\u1ec1u, ba b\u1ec7nh nh\u00e2n y\u00eau c\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1ed5 sung bao g\u1ed3m UAE, nong v\u00e0 n\u1ea1o h\u00fat thai, v\u00e0 misoprostol. V\u00ec th\u1ebf, hi\u1ec7u qu\u1ea3 c\u1ee7a ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb n\u00e0y c\u00f2n nhi\u1ec1u nghi v\u1ea5n.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0110i\u1ec1u tr\u1ecb ph\u1eabu thu\u1eadt<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0110i\u1ec1u tr\u1ecb ph\u1eabu thu\u1eadt ch\u1ec9 n\u00ean \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng cho nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb ch\u1ea3y m\u00e1u n\u1eb7ng ho\u1eb7c khi \u0111i\u1ec1u tr\u1ecb n\u1ed9i khoa k\u1ebft h\u1ee3p v\u1edbi UAE kh\u00f4ng th\u00e0nh c\u00f4ng. Thay v\u00ec ph\u1eabu thu\u1eadt, t\u1ed1t nh\u1ea5t l\u00e0 th\u1ef1c hi\u1ec7n UAE sau khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng methotrexate n\u1ebfu th\u1ea5y c\u1ea7n thi\u1ebft. Th\u1ef1c hi\u1ec7n UAE tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb methotrexate kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn kh\u00edch; n\u00f3 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m v\u1eadn chuy\u1ec3n methotrexate \u0111\u1ebfn m\u00f4 do gi\u1ea3m t\u01b0\u1edbi m\u00e1u t\u1ed5 ch\u1ee9c. M\u1eb7t kh\u00e1c, \u0111i\u1ec1u tr\u1ecb b\u1eb1ng methotrexate \u0111\u01a1n thu\u1ea7n c\u0169ng c\u00f3 x\u00e1c su\u1ea5t th\u00e0nh c\u00f4ng cao, UAE th\u00ec ch\u1ee9ng t\u1ecf \u0111\u01b0\u1ee3c t\u00ednh \u01b0u vi\u1ec7t trong \u0111i\u1ec1u tr\u1ecb CEP trong nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p bao g\u1ed3m ch\u1ea3y m\u00e1u c\u1ea5p t\u00ednh \/ b\u00e1n c\u1ea5p t\u00ednh, UAE tr\u01b0\u1edbc khi n\u1ea1o \u0111\u1ec3 gi\u1ea3m thi\u1ebfu ch\u1ea3y m\u00e1u, v\u00e0 sau khi \u0111i\u1ec1u tr\u1ecb n\u1ed9i khoa (MTX) th\u1ea5t b\u1ea1i.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u1ede nh\u1eefng ph\u1ee5 n\u1eef mu\u1ed1n b\u1ea3o t\u1ed3n kh\u1ea3 n\u0103ng sinh s\u1ea3n v\u00e0 c\u1ea7n ph\u1ea3i ph\u1eabu thu\u1eadt do ch\u1ea3y m\u00e1u nhi\u1ec1u, \u0111i\u1ec1u tr\u1ecb ngo\u1ea1i khoa bao g\u1ed3m th\u1eaft nh\u00e1nh xu\u1ed1ng c\u1ee7a \u0111\u1ed9ng m\u1ea1ch t\u1eed cung, ti\u1ebfp theo l\u00e0 \u0111\u01b0a m\u1ed9t sonde Foley qua c\u1ed5 t\u1eed cung v\u00e0 b\u01a1m b\u00f3ng ho\u1eb7c kh\u00e2u c\u1ed1 \u0111\u1ecbnh \u0111\u1ec3 gi\u1eef sonde b\u00ean trong, sau \u0111\u00f3 \u0111\u1eb7t g\u1eedi v\u00e0o trong \u00e2m \u0111\u1ea1o c\u1ea7m m\u00e1u t\u01b0\u01a1ng \u0111\u1ed1i m\u1edbi b\u1eaft \u0111\u1ea7u n\u1ea1o thai. N\u1ebfu th\u1eddi gian cho ph\u00e9p, n\u00ean th\u1ef1c hi\u1ec7n UAE ch\u1ecdn l\u1ecdc tr\u01b0\u1edbc khi n\u1ea1o \u0111\u1ec3 gi\u1ea3m thi\u1ec3u ch\u1ea3y m\u00e1u, nh\u01b0ng c\u1ea7n nh\u1edb l\u00e0 ch\u1ee7ng l\u00e0m \u1ea3nh h\u01b0\u1edfng t\u1edbi kh\u1ea3 n\u0103ng sinh s\u1ea3n sau n\u00e0y. Ng\u00e0y nay UAE kh\u00f4ng c\u00f2n \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng nhi\u1ec1u.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>K\u1ebft qu\u1ea3<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sau khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng methotrexate \u0111a li\u1ec1u, n\u1ed3ng \u0111\u1ed9 B-hCG huy\u1ebft thanh c\u1ee7a b\u1ec7nh nh\u00e2n t\u0103ng l\u00ean 11,514 IU \/ L v\u00e0o ng\u00e0y th\u1ee9 3 r\u1ed3i b\u1eaft \u0111\u1ea7u c\u00f3 xu h\u01b0\u1edbng gi\u1ea3m. B-hCG ng\u00e0y th\u1ee9 7 l\u00e0 6000 IU \/ L. B\u1ec7nh nh\u00e2n kh\u00f4ng c\u00f3 d\u1ea5u hi\u1ec7u xu\u1ea5t huy\u1ebft k\u1ec3 t\u1eeb khi nh\u1eadp vi\u1ec7n v\u00e0 si\u00eau \u00e2m l\u1ea1i cho th\u1ea5y kh\u00f4ng c\u00f2n ho\u1ea1t \u0111\u1ed9ng t\u00ecm thai, t\u00fai thai d\u1ea7n tho\u00e1i tri\u1ec3n. C\u00f4 \u1ea5y \u0111\u01b0\u1ee3c xu\u1ea5t vi\u1ec7n v\u00e0o ng\u00e0y th\u1ee9 7 sau khi ti\u00eam li\u1ec1u methotrexate cu\u1ed1i c\u00f9ng v\u00e0 \u0111\u01b0\u1ee3c theo d\u00f5i ngo\u1ea1i tr\u00fa h\u00e0ng tu\u1ea7n. N\u1ed3ng \u0111\u1ed9 \u00df-hCG huy\u1ebft thanh ti\u1ebfp t\u1ee5c gi\u1ea3m, v\u00e0 \u1edf tu\u1ea7n th\u1ee9 4, n\u1ed3ng \u0111\u1ed9 hCG \u0111\u00e3 v\u1ec1 m\u1ee9c b\u00ecnh th\u01b0\u1eddng, si\u00eau \u00e2m kh\u00f4ng c\u00f2n th\u1ea5y kh\u1ed1i thai. B\u1ec7nh nh\u00e2n k\u1ebft th\u00fac theo d\u00f5i ngo\u1ea1i tr\u00fa, \u0111\u01b0\u1ee3c d\u1eb7n ph\u1ea3i ch\u00fa \u00fd h\u01a1n \u1edf nh\u1eefng l\u1ea7n mang thai k\u1ebf ti\u1ebfp.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0110\u00fac k\u1ebft l\u00e2m s\u00e0ng<\/strong><\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u2022 Ch\u1ea3y m\u00e1u \u00e2m \u0111\u1ea1o kh\u00f4ng \u0111au sau m\u1ed9t th\u1eddi gian v\u00f4 kinh th\u00ec n\u00ean nghi ng\u1edd c\u00f3 thai \u1edf c\u1ed5 t\u1eed cung, \u0111\u1eb7c bi\u1ec7t khi c\u00f3 c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1. <br>\u2022 Ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb s\u1edbm c\u00f3 th\u1ec3 l\u00e0 bi\u1ec7n ph\u00e1p c\u1ee9u c\u00e1nh v\u00e0 gi\u00fap gi\u1ea3m t\u1ef7 l\u1ec7 bi\u1ebfn ch\u1ee9ng. <br>\u2022 Si\u00eau \u00e2m l\u00e0 ph\u01b0\u01a1ng ph\u00e1p ch\u00ednh \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n CEP<br>\u2022 B\u1ec7nh nh\u00e2n c\u00f3 ch\u1ea9n \u0111o\u00e1n CEP n\u00ean \u0111\u01b0\u1ee3c nh\u1eadp vi\u1ec7n v\u00e0 \u0111i\u1ec1u tr\u1ecb n\u1ed9i tr\u00fa.<br>\u2022 \u1ede b\u1ec7nh nh\u00e2n c\u00f3 huy\u1ebft \u0111\u1ed9ng \u1ed5n \u0111\u1ecbnh, \u0111i\u1ec1u tr\u1ecb n\u1ed9i khoa v\u1edbi methotrexate \u0111a li\u1ec1u l\u00e0 bi\u1ec7n ph\u00e1p h\u00e0ng \u0111\u1ea7u.<br>\u2022 C\u1ea7n \u0111i\u1ec1u tr\u1ecb ph\u1eabu thu\u1eadt ngay l\u1eadp t\u1ee9c khi CEP di\u1ec5n bi\u1ebfn ch\u1ea3y m\u00e1u \u0111e d\u1ecda t\u00ednh m\u1ea1ng. <br>\u2022 M\u1eb7c d\u00f9 hi\u1ebfm g\u1eb7p, nh\u01b0ng c\u1ea7n ph\u1ea3i gi\u1ea3i th\u00edch v\u1edbi b\u1ec7nh nh\u00e2n r\u1eb1ng c\u00f3 th\u1ec3 ph\u1ea3i c\u1eaft b\u1ecf to\u00e0n b\u1ed9 t\u1eed cung \u0111\u1ec3 c\u1ee9u s\u1ed1ng h\u1ecd trong tr\u01b0\u1eddng h\u1ee3p ch\u1ea3y m\u00e1u \u1ed3 at.<\/p><\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abdulrahman Alserri v\u00e0 Togas TulandiTr\u00edch b\u1ea3n d\u1ecbch c\u1ee7a BS Qu\u1ea3n Tr\u1ecdng V\u0169 L\u01b0u \u00fd: to\u00e0n b\u1ed9 n\u1ed9i dung trong c\u00e1c b\u00e0i vi\u1ebft n\u00e0y ch\u1ec9 mang<\/p>\n","protected":false},"author":1,"featured_media":910,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,34,16,5],"tags":[74,42,77],"class_list":["post-908","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-doc-sach-cho-vui","category-ectopic-pregnancy-a-clinical-casebook","category-phu-khoa","category-sieu-am","tag-ep","tag-thai-ngoai-tu-cung","tag-thai-o-co-tu-cung"],"_links":{"self":[{"href":"https:\/\/cdha.edu.vn\/cdha\/wp-json\/wp\/v2\/posts\/908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdha.edu.vn\/cdha\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdha.edu.vn\/cdha\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdha.edu.vn\/cdha\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cdha.edu.vn\/cdha\/wp-json\/wp\/v2\/comments?post=908"}],"version-history":[{"count":4,"href":"https:\/\/cdha.edu.vn\/cdha\/wp-json\/wp\/v2\/posts\/908\/revisions"}],"predecessor-version":[{"id":950,"href":"https:\/\/cdha.edu.vn\/cdha\/wp-json\/wp\/v2\/posts\/908\/revisions\/950"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdha.edu.vn\/cdha\/wp-json\/wp\/v2\/media\/910"}],"wp:attachment":[{"href":"https:\/\/cdha.edu.vn\/cdha\/wp-json\/wp\/v2\/media?parent=908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdha.edu.vn\/cdha\/wp-json\/wp\/v2\/categories?post=908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdha.edu.vn\/cdha\/wp-json\/wp\/v2\/tags?post=908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}